WebUsing siRNA-mediated knockdown of CALCRL coupled with Western blot analyses, ADM signaling transduction was determined in which ADM binds to CALCRL to increase phosphorylation of MTOR, its downstream effectors (4EBP1, P70S6K, and S6), and upstream regulators (AKT and TSC2). WebNov 3, 2024 · However, Akt/mTOR/p70S6K cascade signaling is transitory and only remains active during endurance exercise , being interrupted immediately after training. On the …
The mTOR downstream regulator (p-4EBP1) is a novel …
WebOct 1, 2024 · The regulation of Akt/mTOR/p70S6K axis signaling pathway has been considered to be a potential strategy in anticancer research [20,21,22,23]. Our previous … WebOct 1, 2024 · The regulation of Akt/mTOR/p70S6K axis signaling pathway has been considered to be a potential strategy in anticancer research [20,21,22,23]. Our previous data showed that para-toluenesulfonamide induced an inhibitory effect on the phosphorylation and activation of Akt, mTOR and p70S6K in CRPC . We also tested the Akt/mTOR/p70S6K … how common is ovarian cancer in 20s
The role of mTOR and phospho-p70S6K in pathogenesis …
WebAs for the mTOR pathway, we found that either mTOR or p-mTOR were significantly increased in 231/Gem cells compared with 231 cells, although the downstream proteins of mTOR pathway, p-P70S6K and p-4EBP, were upregulated in 231/Gem cells. Many studies have shown that inhibition of mTOR activity could trigger autophagy. WebDec 13, 2009 · P70S6K is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression. This kinase is controlled by multiple … WebApr 10, 2024 · In the present study, ADM-induced phosphorylation of MTOR, 4EBP1, P70S6K and S6 (direct target of P70S6K) were decreased by siCALCRL, demonstrating that ADM … how many pounds is 1 liter of water