Incidence of rhabdomyolysis with daptomycin

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Webincidence of 2.8% in phase III clinical trials. CASE PRESENTATION: We report the case of 70 years old male patient ... Daptomycin induced rhabdomyolysis is a known possible complication and warrants high level of awareness due to life-threatening potential. … WebNov 23, 2024 · Citation 8 In contrast, a study by Graham et al Citation 9 in 2004 reported an average incidence of 0.44 in 10,000 patients (who developed rhabdomyolysis) being treated with atorvastatin, simvastatin, or pravastatin, with a 95% confidence interval of 0.20–0.84. These patients had been taking lipid-lowering agents alone or in combination.

Rhabdomyolysis during therapy with daptomycin - PubMed

WebWe have encountered numerous cases of rhabdomyolysis associated with acute pesticide intoxication; however, the cause, incidence, and treatment outcomes of rhabdomyolysis have not been studied. The current study involved 2,125 patients hospitalized with acute … WebDaptomycin requires prior approval. Baseline CK followed by weekly CK should be measured in patients placed on daptomycin due to increased risk of rhabdomyolysis. Increased dose of daptomycin may be indicated with documented MRSA bacteremia. Infections due to fungi, mycobacteria, or Actinomyces require longer durations of therapy – retail stores that sell birkenstocks

Rhabdomyolysis from statins: What

WebConsistent with observations regarding calculated distribution volumes, daptomycin protein binding tends to decrease with decreasing renal function, being approximately 88% in patients with creatinine clearance <30 mL/min, approximately 86% in those on hemodialysis, and approximately 84% in those on continuous ambulatory peritoneal dialysis … WebJun 1, 2014 · The incidence of rhabdomyolysis was significantly higher following concomitant daptomycin and statin use than with daptomycin alone (OR = 11.60, 95% CI 1.81-74.37, p=0.01, I2 =0%). WebDaptomycin requires prior approval. Baseline CK followed by weekly CK should be measured in patients placed on daptomycin due to increased risk of rhabdomyolysis. Increased dose of daptomycin may be indicated with documented MRSA bacteremia. Infections due to … prussia-austria war

Daptomycin (Intravenous Route) Side Effects - Mayo Clinic

WebJul 1, 2006 · PDF The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III... Find, read and cite all the research you need ... WebJan 16, 2024 · Rhabdomyolysis means dissolution of skeletal muscle, and it is characterized by leakage of muscle cell contents, myoglobin, sarcoplasmic proteins (creatine kinase, lactate dehydrogenase, aldolase, … retail stores that sell easy spirit shoesWebOct 5, 2024 · The primary outcome was overall incidence of creatine phosphokinase (CK) elevation, myopathy and rhabdomyolysis. Results and discussion A total of 74 patients who received daptomycin therapy were screened with 50 included in the study. retail stores that sell moissanite

"WebAug 1, 2024 · Its exact incidence is difficult to determine because of the lack of prospective studies and underreporting of many mild cases [3]. The disease appears more frequent amongst males, African-Americans, those aged <10 and >60 years old, and in persons with body mass index >40 kg/m 2 [4]. " - Incidence of rhabdomyolysis with daptomycin

Incidence of rhabdomyolysis with daptomycin

Effect of Statin Coadministration on the Risk of …

WebOne patient had no symptoms but elevated CPK levels on day 9; the other experienced pain and weakness on day 10. The overall incidence of CPK elevations was 2.1% in the daptomycin group and 1.4% in the control group, a statistically insignificant difference. WebDaptomycin is reported to cause an elevation in creatine kinase levels, although frank rhabdomyolysis is rare. An even more infrequent occurrence is the simultaneous development of acute kidney injury and drug-induced liver injury with rhabdomyolysis. Daptomycin and rifampin combination are used for synergistic bactericidal action against …

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Webof daptomycin use. Rhabdomyolysis is more commonly seen in a dose-dependent manner, especially at higher doses of daptomycin (8 mg/kg/day) compared to standard doses (6 mg/kg/day) [3]. Here, we described a case of recurrent hyperkalemia when daptomycin was initiated and completely resolved once daptomycin was discontinued. http://cid.oxfordjournals.org/content/42/12/e108.full#:~:text=To%20our%20knowledge%2C%20this%20is%20the%20first%20documented,0.2%25%20of%20the%20study%20population%20reported%20myopathy%20%5B2%5D.

WebJan 16, 2024 · Rhabdomyolysis can occur at any age, but the majority of cases are seen in adults. Males, African-American race, obesity, age more than 60 are factors that demonstrate a higher incidence of rhabdomyolysis. The most common cause for rhabdomyolysis in children is infection(30%). Two or more risk factors might be present in … WebDaptomycin is associated with a number of adverse effects including eosinophilic pneumonia, hypersensitivity reaction, myopathy, rhabdomyolysis, headache and transaminitis. The adverse effects of high-dose daptomycin have not been fully evaluated …

WebDaptomycin, a cyclic lipopeptide antibiotic, has bactericidal activity against Gram-positive organisms ... Although daptomycin causes unique adverse drug reactions such as elevation of creatine phosphokinase or rhabdomyolysis, the detailed ... and incidence of CPK elevation. Second, an in vitro pharmacological study was conducted using cul- WebMay 18, 2024 · Daptomycin is the antibiotic most strongly associated with rhabdomyolysis, with rhabdomyolysis cases totaling 5.5% of daptomycin reports to FAERS, the FDA Adverse Event Reporting System. ... It has been suggested that decreased perioperative fluid administration may decrease the incidence of rhabdomyolysis in the bariatric surgery …

WebNov 17, 2024 · However, the risk of developing rhabdomyolysis from statin therapy is very low, around 1.5 for each 100,000 people taking statins. Rhabdomyolysis or milder forms of muscle inflammation from statins can be diagnosed with a blood test measuring levels of …

Webclinically relevant adverse effects of daptomycin is reversible myopathy, especially when daptomycin is used in high doses. Here, we present a case of a patient with rhabdomyolysis preceded by hyperkalemia retail stores that sell kindleWebDaptomycin has been associated with raised creatine kinase activity, with a reported incidence of 2.8% in phase III clinical trials (167 A). Rhabdomyolysis has also been described (168 A ) . A 45-year-old woman with refractory acute myeloid leukemia was given intravenous daptomycin 550 mg (6 mg/kg) every 24 hours because of bacteremia due to ... retail stores that sell jordansWebMar 7, 2024 · Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp [ 1,2 ]. prussia boundaries