WebNov 9, 2024 · The immune system is a primary line of defense against cancer, and T cells play a major role in tumor immunosurveillance ( 1 ). Tumor cells have been shown to evade responses from tumor-reactive T cells, in part, due to the immunosuppressive features of the tumor microenvironment (TME) ( 2 ). WebOct 5, 2024 · Summary: In this issue, Abrego and colleagues describe an unexpected role for the mitochondrial enzyme glutamic-oxaloacetic transaminase (GOT2) in pancreatic cancer, whereby it acts as a nuclear fatty acid transporter binding to and activating the PPARδ nuclear receptor.
BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression
WebSep 1, 2024 · GOT2 consider the tumor microenvironment September 2024 8 (11) Authors: T. Do Siam Technology College, Bangkok, Thailand Matthew G. Vander Heiden … WebBasic research supported by the Tumor Biology and Microenvironment Branch (TBMB) seeks to understand the role of tumor cells and the tumor microenvironment (TME) in driving cancer initiation, progression, maintenance and recurrence. A comprehensive understanding of the tumor microenvironment, including stromal composition, cell-cell … scott alexander palmer stinson beach
[PDF] Combining ferroptosis induction with MDSC blockade …
WebOct 1, 2024 · A Cancer Cell-Intrinsic GOT2-PPARδ Axis Suppresses Antitumor Immunity. Jaime Abrego Department of Cell, Developmental and Cancer Biology, Oregon Health … WebApr 8, 2024 · Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with clinical features of high metastatic potential, susceptibility to relapse, and poor prognosis. TNBC lacks the expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It is characterized … Web1 day ago · The t-test was used to assess the difference between the two groups, and P < 0.05 was considered to indicate a statistically significant difference (*P < 0.05; **P < 0.01; ***P ... In addition, cancer cell lines are likely not suitable for the in-depth disclosure of tumor microenvironment and heterogeneity [28]. This study transformed high ... scott alexander on agt