WebFeb 3, 2012 · The Elongin BC complex acts as an adaptor connecting Cul and SOCS box proteins. Recently, it was demonstrated that classical SOCS box proteins can be further divided into two groups, Cul2- and Cul5-type proteins. The classical SOCS box-containing protein pVHL is now classified as a Cul2-type protein. WebThe SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene.

RACK1 vs. HSP90: Competition for HIF-1α degradation vs.

WebJul 18, 2000 · Elongin B, initially noted for its role as an elongin C chaperone , binds to elongin C through interactions between β-sheet regions . The binding of elongin B … WebMechanistically, the N-terminal domain of SLC7A11 was specifically recognized by the SH2-structural domain of SOCS2. While the L162 and C166 of SOCS2-BOX region could bind elongin B/C compound to co-form a SOCS2/elongin B/C complex to … pass me fast scam

National Center for Biotechnology Information

WebActive complex of five (5) recombinant human enzymes: VHL amino acids 54-end, full length Elongin C, full length Elongin B, full length Cul2, & full length Rbx1. For use in Enzyme Assays. Function More>> VHL Protein Complex, Active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. … http://elacllc.com/ WebThe elongin B and C proteins bind stably to each other to form an adaptor that links the VHL protein to a Cul2-Rbx1 heterodimeric module. The Cul2-Rbx1 module functions to … passmark score gpu