WebSep 15, 2024 · Cytohubba provides 12 topological methods such as MCC, DMNC, MNC, Degree, EPC, Bottleneck, Eccentricity, Closeness, Radiality, Betweenness, Stress and Clustering co-efficient. The top 10 ranking proteins with neighbours and shortest path were selected using bottleneck scores in the PPI network analysis (Yu et al. 2007 ; Chin et al. … WebWe used the cytoHubba plugin in Cytoscape, which provides 12 topological analysis methods including cluster coefficient, degree, the density of maximum neighborhood component, ... (betweenness, bottleneck, closeness, eccentricity, radiality, and stress) for ranking nodes . If the analyzed genes ranked in the top 10% in more than eight of the ...
Frontiers Identification of Hub Genes and Their Correlation With ...
WebJun 22, 2024 · The Cytohubba plug in the Cytoscape software was used to screen hub genes. TOP 15 nodes were calculated by Degree, Closeness and Radiality methods in Cytohubba. Scores were calculated by the Cytohubba plugin, and the top 11 genes with the most significance in the survival analysis were selected as hub genes according to … WebcytoHubba This project is provided by Institute of Information Science, Academia Sinica. Contact information: Chung-Yen Lin ( [email protected] ); LAB website: … bingham farms pinckneyville il
Hub genes analysis during heart maturation: (A) Upset analysis ...
WebFeb 8, 2024 · The calculation process is completed by Cytoscape plug-in cytoHubba . The subsequent metabolite and microbial gene biological function analysis was completed using the tools of the KEGG mapper (Fig. 1). ... The overlap of the hub members of Radiality and Closeness can show that these nodes all have a central regulatory role. The high degree … WebHere, the common algorithms (MCC, MNC, EPC, Degree, Closeness, Stress, and Radiality) were used to explore the key genes (Su et al., 2024). Subsequently, the GO and KEGG enrichment analysis was ... WebCytoHubba provide a user-friendly interface to explore important nodes in biological networks. It computes all eleven methods in one stop shopping way. Besides, researchers are able to combine cytoHubba with and other plugins into a novel analysis scheme. bingham fellows louisville