Camptothecin prodrug

Author: merm

August undefined, 2024

WebKeywords: CPT prodrug, dual responsive, sequential drug release, prostate-specific membrane antigen, ... Li Y, Lin J, Ma J, et al. Methotrexate–camptothecin prodrug nanoassemblies as a versatile nanoplatform for biomodal imaging-guided self-active targeted and synergistic chemotherapy. WebGlucuronide camptothecin is a type of prodrug produced from camptothecin and glucuronide. Glucuronide, which is also referred to as glucuronoside, is substance produced by linking glucuronic acid to another substance via a glycosidic bond. The prodrug could catalyze and produce the drug camptothecin (CPT), which was discovered in 1966.

A camptothecin prodrug induces mitochondria-mediated …

WebA camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations - Chemical Communications (RSC Publishing) Issue 84, 2024 Previous Article Next Article From the journal: Chemical Communications A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations † National Center for Biotechnology Information can motorcycles drive side by side

A camptothecin prodrug induces mitochondria-mediated apoptosis …

WebEster prodrugs are most often used to enhance the lipophilicity, and thus the passive membrane permeability, of water-soluble drugs by masking charged groups such as carboxylic acids and... WebSep 18, 2024 · Methotrexate–Camptothecin Prodrug Nanoassemblies as a Versatile Nanoplatform for Biomodal Imaging-Guided Self-Active Targeted and Synergistic Chemotherapy ACS Applied Materials & Interfaces ACS ACS Publications C&EN CAS Find my institution Log In Share Share on Facebook Twitter WeChat Linked In Reddit Email … WebHerein, we fabricated a novel amphiphilic lactose-camptothecin prodrug molecular Lac-SS-CPT which can self-assemble into Lac-SS-CPT glyco-nano prodrug system for GSH responsive and targeted drug co-delivery due to the existence of disulfide bond and lactose. 41–44 Then, the CPT-based glyco-nano prodrug system further provides a suitable ... can motorcycle helmets be recycled

Camptothecin Definition & Meaning Merriam-Webster Medical

Camptothecin - an overview ScienceDirect Topics

Web"The self-assembling camptothecin-tocopherol prodrug: An effective approach for formulating camptothecin." Biomaterials. 2015;62:176-87. PMCID: PMC4470812 PMID: 26057133. Title: Lu J, Liu C, Wang P, et al. "The self-assembling camptothecin-tocopherol prodrug: An effective approach for formulating camptothecin." Biomaterials. … WebApr 23, 2024 · Herein, a helix self-assembly camptothecin (CPT) prodrug with simultaneous physical and physiological tumor penetration was constructed to realize effective chemo-immunotherapy. Specifically, CPT was modified with arginine to self-assemble into nanofibers to physically improve tumor penetration. fix hole in oil panWebAug 12, 2024 · Camptothecin (CPT), a potent chemotherapeutic against various cancers, including CRC, has shown the potential to enhance CTL-mediated tumour … can motorcycle drive between lanes

"WebCyclosert- camptothecin is a linear, cyclodextrin-based polymer (CDP) and camptothecin (CPT) conjugate. CPT, an alkaloid extract, displays anticancer activity as an inhibitor of … " - Camptothecin prodrug

Camptothecin prodrug

Chemotherapeutic and targeted agents can modulate the …

WebIntroduction. Camptothecin (CPT) is a naturally occurring alkaloid with potent antineoplastic activity against a broad spectrum of solid tumors (eg, primary and metastatic colon carcinoma, small cell lung carcinoma, and ovarian, breast, pancreatic, and stomach cancers), which inhibits DNA topoisomerase I. 1 SN38 (7-ethyl-10-hydroxyl … WebIt is well known that camptothecin (CPT), which inhibits topoisomerase Ⅰ activity, has significant anticancer activity against various solid tumors in vitro. 29, 30 However, the major problem encountered with CPT is its extremely low solubility and side effects, which lead to the failure of clinical treatment. 31 In order to overcome the problem, …

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WebNov 14, 2003 · Abstract. 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (irinotecan, CPT-11) is a camptothecin prodrug that is metabolized by carboxylesterases (CE) to the active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), a topoisomerase I inhibitor. CPT-11 has shown encouraging antitumor activity against a broad spectrum of …

WebDec 15, 2024 · In this study, we report the synthesis and biological evaluation of the β-glucuronidase-reactive albumin-binding prodrug Mal-glu-CPTS0001 (Fig. 2 A) [40].The … WebFeb 16, 2024 · The aim of this study was to prepare small-molecule camptothecin (CPT) prodrugs and evaluate their effectiveness in colorectal carcinoma therapy. Prodrug nanoparticles (NPs) were physicochemically characterized and evaluated for their cytotoxicity in human colon cancer (HCT116) cell lines. The antitumor efficacy of the NPs …

WebCamptothecin and lactose act as the chemotherapy drug and targeting ligand in the drug delivery system, respectively. Since CPT-S-S-LA is an amphiphilic compound, it can self-assemble into nanoparticles with a diameter of around 110 nm. The CPT-S-S-LA nanoparticles displayed controllable drug release behavior in the physiological environment. WebSep 11, 2007 · Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme …

WebSep 20, 2024 · The construction of prodrug and glucose oxidase coloaded alginate (ALG) hydrogels for PDT-combined chemotherapy of melanoma will provide a promising injectable hydrogel platform for effective treatments of cancer. Biomimetic nanoprodrugs from fatty acid modified camptothecin and albumin for enhanced pharmacotherapy.

WebOct 15, 2006 · A folate receptor targeted camptothecin prodrug was synthesized using a hydrophilic peptide spacer linked to folate via a releasable disulfide carbonate … can motorcycles go in reverseWebJul 12, 2024 · Prodrug–prodrug activation Camptothecin 4 is a topoisomerase I inhibitor that induces S-phase specific cell death. Since its discovery in the 1960's, several camptothecin derivatives and prodrugs have been reported with the aim of overcoming the drawbacks associated with camptothecin such as solubility and the stability of the … can motorcycles go through drive throughsWebA novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed. You have access to this article fix hole in plastic bathtubWebCamptothecin (CPT, 1) is a plant alkaloid from the Camptotheca acuminata tree. 83 In in vitro assay, camptothecin exhibited excellent topoisomerase I inhibitory activity but poor … can motorcycles helmet block bulletsWebFeb 4, 2024 · Conventional chemotherapy and targeted therapy promote the antitumor immune response by increasing the immunogenicity of tumor cells, improving CD8+ T cell infiltration, or inhibiting immunosuppressive cells in the tumor microenvironment. fix hole in plaster wallWebDec 5, 2024 · The highly toxic payloads, for instance, maytansine, camptothecin derivatives, auristatin, or doxorubicin are recommended to choose in the conjugates. 9 Finally, ... To create a TfR targeted prodrug of DM1, the TfR binding peptide B6 was designed to conjugate with DM1 through the side chain of cysteine at the C-terminus via … can motorcycles ride in hov laneWebOct 21, 2024 · A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations. Mitochondria are crucial regulators of the … fix hole in plasterboard wall